viagra drug interaction

viagra drug interaction

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(sildenafil citrate)
Tablets
viagra drug interaction : DESCRIPTION

viagra drug interaction, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective
inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1Hpyrazolo[
4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate and has the
following structural formula:

viagra drug interaction ( Sildenafil citrate )is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in
water and a molecular weight of 666.7. viagra drug interaction (sildenafil citrate) is formulated as blue,
film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of
viagra drug interaction sildenafil for oral administration. In addition to the active ingredient, viagra drug interaction sildenafil citrate, each tablet
contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium
phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose,
triacetin, and FD & C Blue #2 aluminum lake.
CLINICAL PHARMACOLOGY

viagra

viagra drug interaction Mechanism of Action
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the
corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase,
which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth
muscle relaxation in the corpus cavernosum and allowing inflow of blood. viagra drug interaction Sildenafil has no
direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric
oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation
of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO,

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